It refers to a controlled release formula, including: (a) one or more direct release devices, including: (I) carbon free or carbon free; (II) about 4-5% by weight of PVC matrix, such as hydroxypropylcellulose, oxidized polyoxyethylene, 3. Alginato, methylcellulose, etc.; (3) about 0.01% to 0.1% by weight of precursor such as lactose, starch or magnesium stearate; and (b) one or more slow release sub devices, including: (I) no carbohydrate or carbohydrate sa(II) about 20-55% by weight of polycarboxylate, such as hydroxypropylmethylcellulose, polyoxyethane oxidant, alginato, etc.; and (III) about 1.0-30% by weight of soluble enhancers, such as hydroxypropylcellulose, hydroxycellulose, polyketone, polyethylene, etc; (IV) about 0.01% to 25% of precursor chemicals, such as lactose, starch or magnesium stearate. He also mentioned a process This formula provides appropriate bioavailability and long-term release and is useful in the treatment of cardiovascular diseases.
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