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new approach to the synthesis of pimecrolimus enzyme chemistry
new approach to the synthesis of pimecrolimus enzyme chemistry
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机译:吡美莫司酶化学合成的新方法
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摘要
Processes for preparing pimecrolimus starting from ascomycin, exploiting the selectivity characteristics of the purified enzymatic systems particularly regarding the selective deprotection of the hydroxyl groups present in position 33 of ascomycin. Such method represents the first example of chemoenzymatic synthesis for preparing pimecrolimus.
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