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A chemo-enzymatic approach to the synthesis of pimecrolimus
A chemo-enzymatic approach to the synthesis of pimecrolimus
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机译:化学酶法合成吡美莫司
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摘要
Processes for preparing pimecrolimus starting from ascomycin, exploiting the selectivity characteristics of the purified enzymatic systems particularly regarding the selective deprotection of the hydroxyl groups present in position 33 of ascomycin. Such method represents the first example of chemoenzymatic synthesis for preparing pimecrolimus.
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