LIGANDOS OF 5HT6 IN THE INCREASE OF WEIGHT INDUCED BY F�? RMACOS.

摘要

The present invention relates to the use of Compounds binding to the 5HT6 receptor such as sulfonamide compounds of formula I in the manufacture of a medicament for the treatment of weight gain, obesity or associated cardio-metabolic risk factors induced by a therapeutic drug. wherein -- Z either represents =C(R 10 ) or -CH 2 or =N; and wherein either Y represents -S(O 2 )-R 13 , while X represents R 1 ; or X represents R 1 , while Y represents (CH 2 ) n -R 11 or Y represents R 1 , while X represents (CH 2 ) n -R 12 ; while one of R 9a , R 9b , R 9c , or R 9d represents N(R 3 )-S(O 2 )-A, or N-(S(O 2 )-A) 2 .