首页> 外国专利> soluble expressible sequence and structure cristalogr? fies the nuclease domain of UL89 subunit terminase human cytomegalovirus.

soluble expressible sequence and structure cristalogr? fies the nuclease domain of UL89 subunit terminase human cytomegalovirus.

机译:可溶性可表达的序列和结构cristalogr?构成UL89亚基末端酶人巨细胞病毒的核酸酶结构域。

摘要

The invention relates to peptides pertaining to the terminase complex of herpes viruses, preferably the UL89-C protein of cytomegalovirus. The invention also relates to the crystalline form of said peptides, and to the use of same for the screening and/or design of antiviral drugs for the treatment and/or prevention of infections caused by the herpes virus. The invention shows the generation of a soluble peptide comprising the C-terminal region of the UL89 protein (UL89-C) of the human cytomegalovirus. Said peptide maintains the nuclease activity of the complete UL89 protein, having a high solubility, which enables activity studies to be carried out more easily, thereby rendering said peptide highly applicable in the search for useful drugs for the treatment of infections produced by the herpes virus.
机译:本发明涉及与疱疹病毒的末端酶复合物有关的肽,优选巨细胞病毒的UL89-C蛋白。本发明还涉及所述肽的结晶形式,以及其在筛选和/或设计用于治疗和/或预防由疱疹病毒引起的感染的抗病毒药物中的用途。本发明显示了包含人巨细胞病毒的UL89蛋白(UL89-C)的C-末端区域的可溶性肽的产生。所述肽维持具有高溶解度的完整UL89蛋白的核酸酶活性,这使得活性研究更容易进行,从而使所述肽高度适用于寻找用于治疗由疱疹病毒产生的感染的有用药物。 。

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