A new class of histone deacetylase inhibitors.

摘要

Compounds of formula (I) (I) wherein: Q is a bond, CH2, NR5 or oxygen; X is CH or nitrogen; Y is a bond, CH2, oxygen or NR6; Z is CH or nitrogen; R1, R2 are independently hydrogen or C1-C6 alkyl; R3, R4 are independently hydrogen, halogen, C1-C6 alkyl, C1-C6, C1-C6 alkyl or C1-C6 haloalkoxy; R5 is hydrogen, C1-C6 alkyl, (CO) R7, phenyl or benzyl; R6 is hydrogen, C1-C6 alkyl or benzyl; R7 is hydrogen, C1-C6 alkyl, phenyl, benzyl, OR8 or NR9R10; R8 is C2-C6 alkyl; R9 is hydrogen, C1-C6 alkyl phenyl or benzyl; R10 is hydrogen, C1-C6 alkyl or benzyl; and pharmaceutically acceptable salts thereof.