Benzoimidazole compound prostaglandin synthetase capable of inhibiting d.

摘要

Benzimidazole compound represented by Formula (I) wherein X 1 is oxygen or carbonyl, and R 1 is a furan ring having 1 to 3 substituents or a pyrrole ring that may have 1 to 3 substituents, and the substituents in the pyrrole ring or furan ring are selected from the group consisting of halogen, cyano, nitro, C1-6 alkyl which may have one or more substituents, C3-7 cycloalkyl that may have one or more substituents , C2-6alkenyl which may have one or more substituents, and - (C = O) -R 2; R 2 is hydrogen, hydroxy, C1-6 alkyl which may have one or more substituents, C1-6 alkoxy that may have one or more substituents, or -NR 3 R 4; and R 3 and R 4 are the same or different and are each hydrogen, hydroxy, C1-6 alkyl which may have one or more substituents, C1-6 alkoxy that may have one or more substituents, amino, mono- or di (C1- C6 alkyl) amino that may have one or more substituents, C6-14 aryl that may have one or more substituents, or a saturated or unsaturated heterocyclic group which may have one or more substituents, or R 3 and R 4 taken together with the adjacent nitrogen atom, may form a saturated cyclic amino group or unsaturated may have, in the ring structure, 1 or 2 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, in addition atom adjacent nitrogen, and the cyclic amino group may have one or more substituents; or a salt thereof.