COMPOSITIONS AND METHODS FOR TREATING, REDUCING, IMPROVING OR RELIEFING Ophthalmic Diseases of Later Segment.

摘要

A composition comprising: (a) a dissociated glucocorticoid receptor agonist ("DIGRA") having Formula I or a pharmaceutically acceptable salt thereof in which A and Q are independently selected from the group consisting of groups aryl and heteroaryl, substituted with at least one halogen atom, cyano group, hydroxy group, or C1-C10 alkoxy group; R 1 and R 2 and R 3 are independently selected from the group consisting of substituted or unsubstituted C1-C5 alkyl groups; B is a C1-C5 alkylene group; D is the group -NH- or -NR'-, in which R 'is a C1-C5 alkyl group; and E is the hydroxy group; and (b) an anti-inflammatory agent other than said DIGRA and its pharmaceutically acceptable sa wherein said DIGRA or its pharmaceutically acceptable salt and said anti-inflammatory agent are present in said composition in an amount effective to treat, reduce or improve a disease or disorder that is chosen from the group consisting of diabetic retinopathy ("DR "), age-related macular degeneration (" AMD "), diabetic macular edema (" DME ") or one of its combinations; and wherein the composition further comprises a pharmaceutically acceptable carrier.