New methods to build libraries comprising members presented and / or expressed in a diverse family of peptides, polypeptides or prote? Nas and new libraries.

摘要

A method for producing a population or library of immunoglobulin genes comprising the steps of: (i) introducing synthetic diversity in at least one of VH CDR1 or VH CDR2 of those genes; and (ii) combining the diversity from step (i) with VH CDR3 diversity captured from B cells