Modulation of Fas and FasL expression by a synthetic oligonucleotide phosphodiester and anti-Fas antibody

摘要

Using a sequence of synthetic oligonucleotide phosphodiester 6 base selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 18 and an anti-Fas antibody for the manufacture of a medicament for the treatment of a disease selected from a disease neoplastic, an autoimmune disease, an inflammatory disease, a proliferative disease, lymphoproliferative disease, a degenerative disease, a neurodegenerative disease, a cardiovascular disease, graft rejection or infection, wherein the anti-Fas antibody is intended administration at a dose of 0, 003-3 mg / kg, and wherein the oligonucleotide sequence modulates the efficacy of anti-Fas antibody.