Use of PI3K and AKT to induce FOXP3 expression and generate Tregs

摘要

A method of inducing Foxp3 expression in a T cell comprising (i) stimulating a T cell in vitro (ii) inhibit in vitro signaling through PI3K alpha or PI3K delta or m-TOR or Akt in said T cell, wherein said inhibition is commenced 10 to 22 hours after stimulation (i).