buprenorphine transdermal patch for use in the treatment of pain for a dosing interval of at least 7 days

摘要

The transdermal delivery device of buprenorphine comprising a polymer matrix layer containing buprenorphine or a pharmaceutically acceptable salt thereof, for use in treating pain in humans for a dosing interval of at least 7 days, where the transdermal delivery device comprising 10% by weight of buprenorphine base, 10 to 15% by weight of levulinic acid, about 10% by weight of oleyl oleate, 55 to 70% by weight of polyacrylate and between 0 to 10 wt% polyvinylpyrrolidone