HELICOBACTER PYLORI ADHESIN BINDING GROUP ANTIGEN

摘要

A novel Helicobacter pylori blood group antigen binding (BAB) adhesin proteinwas isolated and purified, whereby said protein or fractions thereof bindspecifically to fucosylated blood group antigens. The protein sequence of saidadhesin is disclosed in this application. Simultaneously the DNA sequences fortwo genes, babA and babB, producing highly similar proteins, are disclosed.Said adhesin and/or DNA is useful for diagnose and therapy and/or prophylaxisdirected against H. pylori induced infections, e.g. gastritis and acid pepticdisease, i.e. active vaccination. A new immunoglobulin composition, whichexhibits specific activity to a Lewisb antigen binding Helicobacter pyloriadhesin, or preferably, monoclonal and/or polyclonal antibodies to saidadhesin offer a new and more efficient method of treatment and/or preventionof gastrointestinal diseases, caused by Helicobacter pylori or otherHelicobacter species, i.e. passive vaccination.