COMPOSITION AND METHOD FOR ENHANCING PARACELLULAR TRANSPORT ACROSS CELL LAYERS

摘要

A composition and method for enhancing paracellular transport across celllayers in an animal comprising an antisense oligonucleotide hybridizable witha region of the messenger RNA coding for the protein occludin which, whenhybridized to the occludin mRNA, interferes with its translation such thatoccludin function is disrupted and paracellular permeability is increasedacross an epithelial cell layer or an endothelial cell layer in an animal.