A METHOD FOR ANION-EXCHANGE ADSORPTION AND THIOETHER ANION-EXCHANGERS

摘要

A method for the removal of a substance, which has a negative charge and whichand which is present in an aqueous liquid (I). The method comprises the stepsof: (i) contacting the liquid with an anion-exchanger (1) that comprises mixedmode anion-exchanging ligands in which there is a positively charged nitrogenallowing binding of the substance to the anion-exchanger; and (ii) desorbingsaid substance from said anion-exchanger. The characteristic feature is that(A) the mixed mode ligands have a thioether linkage within a distance of 1-7atoms from their positively charged atom, and (B) the anion-exchanger (1) (i)is capable of binding the substance of interest in an aqueous reference liquid(II) at an ionic strength corresponding to 0.25 M NaCl, and (ii) permits inthe pH interval 2-12 a maximal breakthrough capacity for the substance whichis =200 % of the breakthrough capacity of the substance for Q-Sepharose FastFlow (anion-exchanger 2).