ASSAY FOR SCREENING CANDIDATE DRUGS FOR THE TREATMENT OF INFLAMMATORY DISEASES

摘要

The invention relates to an assay to select a candidate drug for the treatmentof inflammatory disease due to cytokine production. The assay comprises: a)exposing said candidate drug to intestinal cells; and b) analysing the effectof the said candidate drug selected from the group consisting of the variationof nuclear export or import of transcription factors from the NF-.kappa.Bfamily the disruption of transcriptional activity of transcription factorsfrom the NF-.kappa.B family, the differential histone acetylation of p65(RelA); the variation of the amount of PPAR.gamma./RelA complexes in thecytosol of the cells; and the variation in the levels of one or morecytokines. The invention further relates to methods for the treatment ofinflammatory cytokine production associated diseases and to the use of atherapeutically effective dose of Bacteroides thetaiotaomicron or a componentthereof.