Assays for screening candidate drugs for the treatment of inflammatory diseases

摘要

The invention relates to an assay to select a candidate drug for the treatment of inflammatory disease due to cytokine production. The assay comprises: a) exposing said candidate drug to intestinal cells; and b) analysing the effect of the said candidate drug selected from the group consisting of the variation of nuclear export or import of transcription factors from the NF-B family the disruption of transcriptional activity of transcription factors from the NF-B family, the differential histone acetylation of p65 (RelA); the variation of the amount of PPAR/RelA complexes in the cytosol of the cells; and a combination thereof. The invention further relates to methods for the treatment of inflammatory cytokine production associated diseases and to the use of a therapeutically effective dose of Bacteroides thetaiotaomicron or a component thereof.