N-ACYL NITROGEN HETEROCYCLES AS LIGANDS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS

摘要

Compounds of the formula (I) provide pharmacological agents whichbind to Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, thecom-poundsof the instant invention are useful for the treatment of conditions mediatedbythe PPAR receptor activity in mammals. Such conditions include dyslipidemia,hy-perlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia,heart failure,myocardial infarction, vascular diseases, cardiovascular diseases,hypertension, obe-sity,inflammation, arthritis, cancer, Alzheimer's disease, skin disorders,respiratorydiseases, ophthalmic disorders, inflammatory bowel diseases, ulcerativecolitis, Crohn's disease, and conditions in which impairedglucose tolerance, hyperglycemia and insulin resistance are implicated, suchas type-1 and type-2 diabetes, and Syndrome X.