USE OF 2-O DESULFATED HEPARIN FOR THE TREATMENT OF HEPARIN-INDUCED THROMBOCYTOPENIA (HIT) SYNDROME

摘要

A method and medicament for treating and preventing platelet activation orthrombosis in the presence of heparin- and platelet factor 4-complex reactiveantibodies using a 2-O desulfated heparin with an average degree of sulfationof 0.6 sulfate groups per monosaccharide or greater and an average molecularweight or 2.4 kD or greater. The medicament preferably is administeredintravenously, by aerosolization or orally. Preferably, the 2-0 desulfatedheparin medicament includes a physiologically acceptable carrier which may beselected from the group consisting of physiologically buffered saline, normalsaline, and distilled water. Additionally provided is a method of synthesizing2-O desulfated heparin.