Indicator agent for noninflammatory stress response and use thereof

摘要

A system capable of visualization of phenomena within a living organism havingbeen exposed to stress by way of molecular biology to thereby carry out quantitativedetection thereof; and means capable of stress management. There is providedan indicator agent for noninflammatory stress response wherein superoxidesintervene, which indicator agent comprises IL-18. Further, there is provideda visualization agent for noninflammatory stress response used to detect theabove indicator agent, and provided a method of assaying the degree of noninflammatorystress, characterized in that use is made of the visualization agent. Still further,there is provided a method of preventing, improving or prognosticating any variationof immune state attributed to noninflammatory stress response, characterizedin that the above visualization agent is administered to an animal. Still further,there is provided a therapeutic agent for any variation of immune state attributedto noninflammatory stress response, used to lower the amount or activity of indicatoragent mentioned above.