Modified animal lacking functional PYY gene, monoclonal antibodies that bind PYY isoforms and uses therefor

摘要

The present invention provides transgenic animals having a reduced level of expressionof peptide YY (PYY) and drug screening platforms using the transgenic animalsfor identifying agonists and antagonists of PYY. The present invention furtherprovides monoclonal antibodies that bind specifically to full-length PYY[1-36]or the processed form thereof i.e., PYY[3-36] and to diagnostic and drug screeningplatforms using the monoclonal antibodies. The invention has particular utilityfor the diagnosis of a predisposition or risk of a subject becoming obese, developingone or more pathologies associated with obesity, or developing a disease/disorderof bone tissue.