Treatment of brain metastases with inhibitors of endothelin receptors in combination with a cytotoxic chemotherapy agent

摘要

The disclosure relates to an endothelin receptor antagonist for use in the prevention or treatment of brain metastases in combination with a cytotoxic chemotherapy agent, radiotherapy or both. The endothelin receptor antagonist may for example be bosentan, macitentan or a mixture of bosentan and macitentan.