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Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
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机译:哮喘相关因素作为特应性过敏症(包括哮喘和相关疾病)的治疗目标
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#$%^&*AU2011265475A120120119.pdf#####ABSTRACT A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAFL. When this substitution occurs in both alleles in one individual, it is associated with less evidence of atopic allergy including asthma, fewer abnormal skin test responses, and a lower serum total IgE. Thus, applicant has identified the existence of a non-asthmatic, non-atopic phenotype characterized by methionine at codon 117 when it occurs in both AAFI gene products in one individual.
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