COMPOSITIONS FOR USE IN NEUROLOGICAL OR NEURODEGENERATIVE DISEASES WITH A GENETIC DISORDER BACKGROUND COMPRISING 4-PHENYL-BUTYRIC ACID AND ITS SALTS

摘要

The present invention refers to pharmaceutical compositions comprising the histone hyperacetylating agent phenyl -butyric acid, or a physiologically acceptable salt thereof for use in the treatment of a genetic disorder, especially of an epigenetic disorder, which is or manifests itself in a neurological or neurodegenerative disease, like treatment of Rubinstein-Taybi syndrome, Rett syndrome, Friedreich's ataxia, Huntigton's disease, Parkinson's disease, amyotrophic lateral sclerosis or depression with a genetic disorder background.