PHARMACEUTICAL COMPOSITION FOR INCREASING CELLULAR HYPOXIC TOLERANCE

摘要

The present inventors have discovered a new class of cryoprotective therapeutic agents which make it possible for mammalian cells to survive for longer periods of time under hypoxic conditions, and to prevent problems linked to oxygen deprivation in a model of renal failure due to ischemic lesion in rats and of cardiac stroke. The present invention is therefore directed towards a pharmaceutical composition for preventing and/or treating pathological conditions resulting from hypoxic conditions and/or from ischemic lesions in a mammal, said composition comprising, as cytoprotective agent, an elF5A-hypusination-inhibiting agent, such as, for example, N1-guanyl-1,7-diaminoheptane (GC7).