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A RECOMBINANT STRAIN OF THE BACTERIUM BRUCELLA SPP AND LIVE VACCINE AGAINST BRUCELLOSIS

机译：布鲁氏菌属细菌的SPP重组菌株和布鲁氏菌病活疫苗

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摘要

The recombinant strain S2308Δpgk of Brucella abortus S2308 is obtained by partially or completely deleting the pgk gene. This attenuated strain induces greater protective immunity in 129/Sv and IRF-1 KO mice compared to the commercial strains S19 or RB51, and induces protective immunity in BALB/C and C57BL/6 mice similar to that of strain S19, having the potential to be tested as a new live vaccine against brucellosis. Other recombinant strains of the bacterium Brucella obtained by partially or completely deleting the pgk gene, with different levels of attenuation, are described.

机译：流产布鲁氏菌S2308的重组菌株S2308Δpgk是通过部分或完全缺失pgk基因而获得的。与市售品系S19或RB51相比，这种减毒品系在129 / Sv和IRF-1 KO小鼠中诱导出更大的保护性免疫力，并且与在品系S19中相似，在BALB / C和C57BL / 6小鼠中诱导出保护性免疫力，可能具有作为抗布鲁氏菌病的新活疫苗进行测试。还描述了通过部分或完全缺失pgk基因而减弱程度不同的细菌 Brucella 的其他重组菌株。 展开▼

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公开/公告号WO2012016315A1

专利类型

公开/公告日2012-02-09

原文格式PDF

申请/专利权人 UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG;COSTA OLIVEIRA SERGIO;
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申请/专利号WO2011BR00276

发明设计人 COSTA OLIVEIRA SERGIO;
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申请日2011-08-04

分类号A61K39/10;C12N1/36;C12N15/54;

国家 WO

入库时间 2022-08-21 17:17:58

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