BRUCELLA SPP RECOMBINANT BACTERIA CEPA AND LIVE VACCINE AGAINST BRUCELLOSIS

摘要

RECOMBINANT CEPA OF BRUCELLA SPP BACTERIA AND LIVE VACCINE AGAINST BRUCELLOSIS The recombinant strain S23O8Apgk of Brucelia abortus S2308 is obtained by partial or complete deletion of the pgk gene. This attenuated strain induces protective immunity in 129ISv and IRF-1 KO mice greater than the commercial S19 or RB5I strains, and equal protection to the S19 strain in BALB / C and 057BL / 6 mice, with the potential to be tested as a new live vaccine. against brucellosis. Other recombinant strains of the Bruceila bacterium obtained by partial or complete deletion of the pgk gene, with varying levels of attenuation, are described.