IMMUNOGENIC COMPOSITIONS COMPRISING ALPHAVIRUS VECTORED DENGUE VIRUS E PROTEIN ANTIGENS

摘要

The present invention provides an alphavirus vector comprising a dengue virus E protein antigen. Also provided are nucleic acids encoding or comprising the same. Also provided are multivalent compositions and pharmaceutical formulations comprising two or more alphavirus vectors or nucleic acids of the invention. The invention further provides methods of administering the alphavirus vectors, nucleic acids, compositions and/or pharmaceutical formulations to a subject, e.g., to induce an immune response against dengue virus, to treat dengue virus infection, to prevent dengue virus infection and/or to protect a subject from the effects of dengue virus infection.