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METHODS OF USING MIRNAS TRANSCRIBED FROM THE 14Q32 REGION OF HUMAN CHROMOSOME 14 AS BIOMARKERS FOR SCHIZOPHRENIA OR SYMPTOMS THEREOF
METHODS OF USING MIRNAS TRANSCRIBED FROM THE 14Q32 REGION OF HUMAN CHROMOSOME 14 AS BIOMARKERS FOR SCHIZOPHRENIA OR SYMPTOMS THEREOF
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机译:将人类染色体14的14Q32区域转录的MIRNA用作精神分裂症或其症状的生物标记的方法
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摘要
Provided herein are methods for detecting a risk profile for schizophrenia or a manifestation thereof or a sub-threshold phenotype or state thereof in a subject, comprising identifying a reduction or down regulation in expression of one or more miRNAs disclosed herein, or a molecule that regulates the expression of said miRNA, in blood from the subject wherein the reduction or down regulation of expression is indicative of a risk of the subject having or developing symptoms of schizophrenia. Also provided are methods of diagnosing schizophrenia based on the expression profiles of the miRNAs and miRNA regulatory molecules disclosed herein, and methods for treating schizophrenia by modulating the expression of said miRNAs and regulatory molecules.
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