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RECOMBINANT PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEINS 4 AND 5 AND THEIR USE

机译：重组恶性疟原虫裂殖子表面蛋白4和5及其用途

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摘要

The invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.

机译：本发明提供了其中编码恶性疟原虫MSP4和MSP5的核酸以及所得多肽已被修饰的构建体。更具体地说，本发明提供了编码重组MSP4和MSP5多肽的构建体，它们在杆状病毒-昆虫细胞表达系统中表达为可溶性分泌多肽。令人惊讶地发现重组多肽在C末端包含正确折叠在多肽中的EGF样结构域。

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公开/公告号EP1954305B1

专利类型
公开/公告日2012-09-19

原文格式PDF
申请/专利权人 INSTITUT PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;
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申请/专利号EP20060842385
发明设计人 LONGACRE SHIRLEY;POLSON HANNAH;PERRAUT RONALD;NATO FARIDA;
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申请日2006-11-23
分类号A61K39/015;C07K14/445;C07K16/20;
国家 EP
入库时间 2022-08-21 17:17:06

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1. Role of toll-like receptor 4 in eliciting adaptive immune responses against recombinant BCG expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum [J] . Muhammad A.Abbas, Rapeah Suppian 亚太热带生物医学杂志（英文版） . 2019,第001期

2. Role of toll-like receptor 4 in eliciting adaptive immune responses against recombinant BCG expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum [J] . Muhammad A.Abbas, Rapeah Suppian 亚太热带生物医学杂志：英文版 . 2019,第001期

3. Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1 [J] . Mohamed H Abdikarim, Muhammad A Abbas, Munirah N Zakaria, 亚太热带生物医学杂志（英文版） . 2019,第007期

4. Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1 [J] . Mohamed H Abdikarim, Muhammad A Abbas, Munirah N Zakaria, 亚太热带生物医学杂志：英文版 . 2019,第007期

5. Role of toll like-receptor 2 in inflammatory activity of macrophage infected with a recombinant BCG expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum [J] . Nor Munirah Zakaria, Rapeah Suppian, Norazmi Mohd Nor, 亚太热带生物医学杂志（英文版） . 2018,第007期

6. Immunization of Saimiri sciureus Monkeys with a Recombinant Hybrid Protein Derived from the Plasmodium falciparum Antigen Glutamate-Rich Protein and Merozoite Surface Protein 3 Can Induce Partial Protection with Freund and Montanide ISA720 Adjuvants [J] . Leonardo J. M. Carvalho, Francisco A. Alves, Cesare Bianco, Clinical and diagnostic laboratory immunology . 2005,第2期

7. The Plasmodium vivax homologues of merozoite surface proteins 4 and 5 from Plasmodium falciparum are expressed at different locations in the merozoite. [J] . Black CG, Barnwell JW, Huber CS, Molecular and Biochemical Parasitology . 2002,第2期

8. Immunogenic properties of a recombinant fusion protein containing the C-terminal 19 kDa of Plasmodium falciparum merozoite surface protein-1 and the innate immunity agonist FliC flagellin of Salmonella Typhimurium. [J] . Bargieri D. Y., Leite J. A., Lopes S. C. P., Vaccine . 2010,第16期

9. Compositional Analysis of the Merozoite Surface Protein-1 Complex of Plasmodium falciparum using Blue Native PAGE and Protein Correlation Profiling [C] . Nicole Sessler, Karsten Krug, Mirita Franz-Wachtel, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

10. Plasmodium falciparum merozoite surface protein networks and host protein interactions. [D] . Sasser, Todd. 2004

11. Immunization of Saimiri sciureus Monkeys with a Recombinant Hybrid Protein Derived from the Plasmodium falciparum Antigen Glutamate-Rich Protein and Merozoite Surface Protein 3 Can Induce Partial Protection with Freund and Montanide ISA720 Adjuvants [O] . Leonardo J. M. Carvalho, Francisco A. Alves, Cesare Bianco Jr., 2005

12. Immunization of Saimiri sciureus Monkeys with a Recombinant Hybrid Protein Derived from the Plasmodium falciparum Antigen Glutamate-Rich Protein and Merozoite Surface Protein 3 Can Induce Partial Protection with Freund and Montanide ISA720 Adjuvants [O] . Carvalho, Leonardo J. M., Alves, Francisco A., Bianco, Cesare, 2005

13. Production of a Recombinant E. coli Expressed Malarial Vaccine from the C-Terminal Fragment of Plasmodium Falciparum 3D7 Merozoite Surface Protein-1 [R] . Angov, E. 2000

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