ARIH2 REGULATES DENDRITIC CELL ACTIVATION AND AUTOIMMUNITY

摘要

Arih2 negatively regulates dendritic cell (DC) activation and inhibits NFĸB signaling. Methods and compositions are provided for suppressing immune response, reducing chronic inflammation, treating autoimmune diseases, preventing diabetes and inhibiting dendritic cell activation by increasing the biological activity of Arih2. Also provided are methods and compositions for enhancing immune response, treating infections, treating cancer and enhancing DC activation by decreasing the biological activity of Arih2.