AN IMPROVED PROCESS FOR THE PREPARATION OF RACEMIC 6, 6- DIMETHYL-3-AZABICYCLO-3.1.0-HEXANE AND ITS SALTS, A KEY RAW MATERIAL FOR HCV INHIBITOR.

摘要

The present invention discloses an efficient and economical process for the preparation of racemic 6, 6-dimethyl-3-azabicyclo-[3.1.0]-hexane of formula I and its salts. The invention relates to the compounds of formulae I and II. The compound of formula I is a key raw material for the preparation of a key intermediate (1R, 2S, 5S) - methyl 6,6-dimethyl -3-azabicyclo [3.1.0] hexane-2 carboxylic acid and ester and salts of formula III for a class of inhibitors of the protease of the formula PI. Among the compounds provided herein, compounds those inhibit HCV NS3/NS4a serine protease activity are preferred.