MAIN IMMUNOPROTECTIVE DOMAINS AND EPITOPES OF NUCLEOSIDE HYDROLASE FROM LEISHMANIA (L) DONOVANI FOR USE IN VACCINATION, IMMUNOTHERAPY AND DIAGNOSIS

摘要

The present innovation relates to the identification of the main sequences of the protein nucleoside hydrolase from Leishmania (L) donovani, to be included in a recombinant, DNA or synthetic vaccine to protect and cross-protect against leishmanioses. It also relates to the identification of the main epitopes that react with antibodies to be used in the immunodiagnosis of leishmanioses, and to the use thereof to give cross-protection against other micro-organisms having a sequence in common in the nucleoside hydrolases thereof.