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METHOD FOR EVALUATION OF DEVELOPMENTAL TOXICITY
METHOD FOR EVALUATION OF DEVELOPMENTAL TOXICITY
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机译:评价发育毒性的方法
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摘要
The present invention provides a method for assessing embryotoxicity of a chemical comprising: (1) a first step of measuring the expression level of one or more genes selected from among genes each comprising any of the nucleotide sequences of SEQ ID NOs: 1 to 78 and 101 to 230 and orthologous genes thereof in a sample from a non-human mammal or mammalian cell which has come into contact with a test chemical; and (2) a second step of comparing the measured value of the expression level of the gene in the sample obtained in the first step with a control value of the expression level of the gene and based on the difference assessing the level of the embryotoxicity of the test chemical in the sample; and so on.
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机译:本发明提供了一种评估化学品的胚胎毒性的方法,其包括:(1)测量一个或多个基因的表达水平的第一步,所述一个或多个基因选自各自包含SEQ ID NO:1-78的任何核苷酸序列的基因,以及来自非人类哺乳动物或哺乳动物细胞的样品中已经与测试化学品接触的101至230及其直系同源基因; (2)第二步,将第一步获得的样品中的基因表达水平的测量值与基因表达水平的对照值进行比较,并根据差异来评估胚胎的胚胎毒性水平。样品中的测试化学品;等等。
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