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Use of toll-like receptor ligands in treating excitotoxic injury, ischemia and/or hypoxia
Use of toll-like receptor ligands in treating excitotoxic injury, ischemia and/or hypoxia
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机译:Toll样受体配体在治疗兴奋性毒性损伤,局部缺血和/或缺氧中的用途
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摘要
Methods of protecting cells against cytotoxic insults are provided. The methods involve administering a composition including a Toll-like receptor (TLR) ligand, for instance a TLR7, TLR8, or TLR9 ligand to a subject. The methods are applicable to the protection of neural and non-neural cells. For example, methods of protecting a neural cell against excitotoxic brain injury are provided. Methods for preparing medicaments for the prophylactic treatment of excitotoxic injury, ischemia and/or hypoxia are also provided. Also provided are compositions for use in the described methods.
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