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NOVEL PROTEIN HAVING FRUCTOSYL VALYL HISTIDINE OXIDASE ACTIVITY AND MODIFIED PRODUCT THEREOF, AND USE OF THE PROTEIN OR THE MODIFIED PRODUCT
NOVEL PROTEIN HAVING FRUCTOSYL VALYL HISTIDINE OXIDASE ACTIVITY AND MODIFIED PRODUCT THEREOF, AND USE OF THE PROTEIN OR THE MODIFIED PRODUCT
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机译:具有果糖基戊基组氨酸氧化酶活性的新型蛋白质及其修饰产物,以及该蛋白质或修饰产物的用途
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摘要
The present invention provides: a protein having a fructosyl amino acid oxidase activity which protein is useful for measurement of a glycosylated protein (particularly, glycosylated hemoglobin); a modified protein thereof; and use of the protein or the modified protein. The protein of the present invention is, for example, a fructosyl valyl histidine oxidase derived from Phaeosphaeria nodorum, the fructosyl valyl histidine oxidase having excellent thermal stability and substrate specificity and also having a small Km value to fructosyl valyl histidine. This allows a glycosylated protein measuring reagent to be stored in a long time and measurement accuracy of the glycosylated protein measuring reagent to be improved.
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