The present invention provides: a tie-2 activator comprising the extracts of the stem branch or seed of sokakushi (Gleditsia sinensis Lam.), polygonatum rhizome (Polygonatum sibiricum Red.), Angular Solomon's Seal (Polygonatum officinalle), the fruit or seed of trichosanthes (Trichosanthes kirilowii Maxim), and/or Indian Mulberry (Morinda officinalis How.); an agent for maturation, normalization, or stabilization of blood vessels and a lymph vessel stabilizing agent; and a wrinkle prevention/improvement agent and edema improvement/prevention agent that are characterized by being a combination of the activator and agents.
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