The present invention provides: a Tie-2 activator comprising one or more types of compounds selected from a group consisting of Eleutheroside E, Eleutheroside E1, Sesamin, Eudesmine, Sylvatesmin, Pinoresinol, Yangambin, Forsythinol, and Coumarine; an agent for maturation, normalization, or stabilization of blood vessels and a lymph vessel stabilizing agent that contain the activator; and a wrinkle prevention/improvement agent and edema improvement/prevention agent that are characterized by being a combination of the agents.
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