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Process for the synthesis of beta-amino acids and derivatives thereof
Process for the synthesis of beta-amino acids and derivatives thereof
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机译:β-氨基酸及其衍生物的合成方法
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摘要
The present invention relates to a process for the preparation of β-amino acids and derivatives thereof, which is especially suited for gliptins and particularly sitagliptin. A key step makes use of suitably derivatized epoxides or aziridines, which owing to a chirality provides a source of chirality for intermediates which are suitable for building up β-amino acids and similar compounds, in particular in the construction of the sitagliptin molecule.
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