PHARMACEUTICAL COMPOSITIONS OF ACTIVE PHARMACEUTICAL INGREDIENT COMPRISING SULPHONYLUREA MOIETY WITH EXCELLENT DISSOLUTION PROPERTIES

摘要

The present invention provides a pharmaceutical composition comprising at least one sulphonylurea-based active pharmaceutical ingredient, wherein the at least one sulphonylurea-based active pharmaceutical ingredient is intimately mixed with a basic agent. The weight ratio of the basic agent and the at least one sulphonylurea-based active pharmaceutical ingredient is from above 1:1 to 50:1, especially from 1.1:1 to 50:1, preferably from 1.5:1 to 25:1, more preferably from 2:1 to 15:1, yet more preferably from 3:1 to 10:1. The pharmaceutical composition can be obtained by simply mixing sulphonylurea-based active pharmaceutical ingredient and the basic agent in the aforementioned weight ratio, optionally in the presence of the granulation liquid. Alternatively, the pharmaceutical composition can be obtained by at least partially or fully dissolving the compounds in the granulation liquid or solvent, and at least partly precipitating them. The invention provides improved dissolution properties of the sulphonylurea-based active pharmaceutical ingredient.