METHOD AND SYSTEM FOR REGULATING GAS TEMPERATURE IN A CRYOGENIC CHILLER

摘要

A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogenic cold gas being introduced to the system as a function of time. The cyrogenic cold gas temperature profile is created through the operative control of a mixer that blends liquid nitrogen with warmer nitrogen gas.