PEPTIDE NUCLEIC ACID PROBES, KIT AND METHOD FOR DETECTING HELICOBACTER PYLORI AND/OR CLARITHROMYCIN RESISTANCE PROFILE AND APPLICATIONS

摘要

Four peptide nucleic acid probes (PNA) are for the detection of Helicobacter pylori and/or response analysis of Helicobacter pylori strains to clarithromycin. The probes are based in molecular biology methods, namely fluorescence in situ hybridization (FISH) that are used in H. pylori clarithromycin susceptibility diagnosis in several sample types, including clinical isolates and biopsies. Due to physical and chemical characteristics inherent in its structure, the probes allow a faster and more sensitive hybridization. A kit may use one or several probes described here and the related process of detection or quantification. The kit identifies H. pylori and its response to clarithromycin in clinical samples.