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Amino acid compound and use of same for treating intrauterine growth restriction (IUGR) and for parenteral feeding of extremely premature infants

机译:氨基酸化合物及其在治疗宫内生长受限(IUGR)和极早产儿肠胃外喂养中的用途

摘要

Composition comprises a mixture of amino acids or their synthetic or modified amino acid analogues or substitutes including e.g. isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, arginine, histidine, ornithine, glycine, alanine, proline , aspartate and asparagine. The amino acid present in the mixture is present in concentrations or concentration ratios, which correspond to the physiological amino acid concentrations or concentration ratios in the blood plasma of a healthy fetus in intrauterinein the 24-34 weeks of pregnancy. Composition comprises a mixture of amino acids or their synthetic or modified amino acid analogues or substitutes including isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, arginine, histidine, ornithine, glycine, alanine, proline , aspartate, asparagine, glutamate, glutamine, serine, tyrosine, taurine, hydroxyproline, citrulline or cysteine. The amino acid present in the mixture is present in concentrations or concentration ratios, which correspond to the physiological amino acid concentrations or concentration ratios in the blood plasma of a healthy fetus in intrauterinein the 24-34 weeks of pregnancy, where the amino acids concentrations or concentration ratios in the blood plasma of the fetus in intrauterinein are determined by collecting and analyzing the cord blood. ACTIVITY : Anabolic. MECHANISM OF ACTION : None given.
机译:组合物包含氨基酸或其合成或修饰的氨基酸类似物或替代物的混合物,包括例如氨基酸。异亮氨酸,亮氨酸,赖氨酸,蛋氨酸,苯丙氨酸,苏氨酸,色氨酸,缬氨酸,精氨酸,组氨酸,鸟氨酸,甘氨酸,丙氨酸,脯氨酸,天冬氨酸和天冬酰胺。存在于混合物中的氨基酸以浓度或浓度比存在,其对应于怀孕24-34周内子宫内健康胎儿血浆中的生理氨基酸浓度或浓度比。组合物包含氨基酸或其合成或修饰的氨基酸类似物或替代物的混合物,包括异亮氨酸,亮氨酸,赖氨酸,蛋氨酸,苯丙氨酸,苏氨酸,色氨酸,缬氨酸,精氨酸,组氨酸,鸟氨酸,甘氨酸,丙氨酸,脯氨酸,天冬氨酸,天冬酰胺,谷氨酸,谷氨酰胺,丝氨酸,酪氨酸,牛磺酸,羟脯氨酸,瓜氨酸或半胱氨酸。混合物中存在的氨基酸的浓度或浓度比对应于怀孕24-34周内子宫内健康胎儿血浆中的生理氨基酸浓度或浓度比。通过收集和分析脐带血来确定子宫内子宫内胎儿胎儿血浆中的血药浓度比。活动:合成代谢。作用机理:未给出。

著录项

  • 公开/公告号EP2489408A1

    专利类型

  • 公开/公告日2012-08-22

    原文格式PDF

  • 申请/专利权人 TCHIRIKOV MICHAEL;

    申请/专利号EP20110000211

  • 发明设计人 TCHIRIKOV MICHAEL;

    申请日2011-01-13

  • 分类号A61P15/06;A23L1/305;A61K31/198;A61P43;

  • 国家 EP

  • 入库时间 2022-08-21 17:12:01

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