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NON-DNA BASE-CONTAINING POLYNUCLEOTIDE COMPOSITIONS AND THEIR USE FOR THE MODULATION OF IMMUNE RESPONSES
NON-DNA BASE-CONTAINING POLYNUCLEOTIDE COMPOSITIONS AND THEIR USE FOR THE MODULATION OF IMMUNE RESPONSES
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机译:含非DNA碱基的多核苷酸组合物及其在免疫反应调节中的用途
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摘要
The present invention provides compositions comprising synthetic non-DNA base-containing polynucleotide sequences of 3 to 30 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases, in combination with a pharmaceutically acceptable vehicle, particularly one or more adjuvant vehicle, and one or more antigen. The present invention relates to methods of administering these compositions for inducing or modulating an immune response in vitro or in vivo, and particularly for activating antigen presenting cells.
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