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Novel N,N'-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells
Novel N,N'-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells
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机译:新型N,N'-肼基双Isatin衍生物具有对多药耐药癌细胞的选择性活性
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摘要
The invention, is directed to a compound of Formula (I),wherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R1 is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; X is selected from the group consisting of hydrogen atom or halogen atom; and Y is selected from the group consisting of hydrogen atom, halogen atom, C1-C4 alkyl group, nitro group, and -OCF3 group, as well as for its use in therapy, preferably for the treatment of cancer, and to a related pharmaceutical composition, the use of the compound for the manufacture of a medicament for the respective medical indication, and a method of synthesis of the compounds of the invention.
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机译:本发明涉及式( I B>)的化合物, <图像文件=“ IMGA0001.GIF” he =“ 44” imgContent =“ chem” imgFormat =“ GIF” wi =“ 49” /> Chemistry>其中R选自氢原子和未取代或取代的苯基; R 1 Sub>选自氢原子和未取代或取代的苯基; X选自氢原子或卤素原子; Y选自氢原子,卤素原子,C 1 Sub> -C 4 Sub>烷基,硝基和-OCF 3 Sub化合物及其在治疗中,优选在治疗癌症中的用途以及相关药物组合物,化合物在制备用于相应医学适应症的药物中的用途及其合成方法本发明的化合物。
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