N,N′-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells

摘要

The invention is directed to a compound of Formula (I),; wherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R₁ is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; X is selected from the group consisting of hydrogen atom or halogen atom; and Y is selected from the group consisting of hydrogen atom, halogen atom, C₁-C₄ alkyl group, nitro group, and —OCF₃ group, as well as for its use in therapy, preferably for the treatment of cancer, and to a related pharmaceutical composition, the use of the compound for the manufacture of a medicament for the respective medical indication, and a method of synthesis of the compounds of the invention.