UNDIFFERENTIATED MESENCHYMAL STEM CELLS WITH ENHANCED SELF-RENEWAL ABILITY AND OSTEOGENIC POTENTIAL

摘要

PURPOSE: An undifferneitated mesenchymal stem cell with enhanced cell proliferation ability and self-renewal ability is provided to treat bone metabolic diseases.;CONSTITUTION: An undifferneitated mesenchymal stem cell has Oct4 expression ability, 20% or more of CFU-F(colony forming unit-fibroblast) colonization, expression ability of osteopontin, osteocalcin, and ALP(alkaline phosphatase), nestin expression ability. A composition for treating bone metabolic syndrome contains the mesenchymal stem cells. The mesenchymal stem cells are prepared by in vitro culture of human umbilical cord blood serum.;COPYRIGHT KIPO 2012