ISCHEMIA-SPECIFIC GENE EXPRESSION SYSTEM USING TYROSINE HYDROXYLASE 3' UTR

摘要

PURPOSE: An effective expression system of low oxygen-selective therapeutic gene using tyrosine hydroxylase 3' UTR is provided to treat ischemic diseases.;CONSTITUTION: A recombinant vector for ischemia-specific expression contains a promoter, ischemia therapeutic gene, and tyrosine hydroxylase 3' UTR(untranslated region) sequence fused at the gene terminal. The ischemia therapeutic gene is a vascularization factor, such as basic fibroblast growth factor(bFGF), vascular endothelial growth factor(VEGF), plateletderived growth factor(PDGF), hepatocyte growth factor(HGF), heme oxygenase 1(HO-1), insulin growth factor(IGF-I or II), heat shock protein 27(HSP27), or tymidine kinase. A pharmaceutical composition for treating ischemia contains the recombinant vector as an active ingredient.;COPYRIGHT KIPO 2012