Polymer nanoparticles coated with phasin or PHA depolymerase and its preparation method

摘要

PURPOSE: A method for effectively manufacturing polymer nanoparticles coated with phasing and PHA dipolymerase is provided. CONSTITUTION: A composition for forming nanoparticles contains phasing or PHA(polyhydroxyalkanoic acid) depolymerase and poly(3-hydroxybutylate) or poly(3-hydroxybutylate-co-3-hydroxyvalate) biocompatible polymer. The composition further contains anion surfactant or cation surfactant. The phasing is originated from Ralstonia eutropha. The PHA dipolymerase is originated from Hydrogenophaga pseudoflava. A method for manufacturing biocompatible polymer nanoparticls comprises: a process of preparing oil phase solution in which biocompatible polymer is dissolved in organic solvent; and a step of adding a composition for forming nanoparticles in oil phase solution to form emulsion.