- NOVEL IMMUNOGENIC LIPOPEPTIDES COMPRISING T-HELPER AND CYTOTOXIC T LYMPHOCYTE CTL EPITOPES

摘要

The present invention provides synthetic immunogenic lipopeptide molecules comprising T-helpers and CTL epitopes on a common line and methods for their preparation, and uses for inducing primary and secondary immune responses against particular CTL epitopes and vaccines against animal subjects. Provides use for inoculation. More specifically, the present invention provides highly soluble lipopeptides wherein the lipid moiety is bound to the terminal side chain group of the internal lysine or lysine analog, preferably to the terminal side chain group of the internal diamino acid residue. Preferably, the internal lysine or lysine analog is disposed between the T-helper epitope and the CTL epitope or within the T-helper epitope.;T-helper cells, cytotoxic T lymphocytes, epitopes, immunogens, lipopeptides, lipids